Téléchargez le livre : Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation

Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation

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Éditeur :

Springer


Collection :

Springer Theses

Paru le : 2020-03-20

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Description
This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in varioushuman diseases.
Pages
163 pages
Collection
Springer Theses
Parution
2020-03-20
Marque
Springer
EAN papier
9789811525087
EAN PDF
9789811525094
Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
16
Taille du fichier
11489 Ko
Prix
94,94 €
EAN EPUB
9789811525094
Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
16
Taille du fichier
49050 Ko
Prix
94,94 €

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