Téléchargez le livre : Development of In-Tether Carbon Chiral Center-Induced Helical Peptide

Development of In-Tether Carbon Chiral Center-Induced Helical Peptide

Methodology and Applications de

Éditeur :

Springer


Collection :

Springer Theses

Paru le : 2021-01-26

eBook Téléchargement , DRM LCP 🛈 DRM Adobe 🛈
Lecture en ligne (streaming)
168,79 €
Téléchargement immédiat
Dès validation de votre commande
Image Louise Reader présentation

Louise Reader

Lisez ce titre sur l'application Louise Reader.

badge apple Application Louise Reader
badge Android Application Louise Reader
Description

This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. 
Pages
102 pages
Collection
Springer Theses
Parution
2021-01-26
Marque
Springer
EAN papier
9789813366121
EAN PDF
9789813366138
Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
10
Taille du fichier
6584 Ko
Prix
168,79 €
EAN EPUB
9789813366138
Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
10
Taille du fichier
38410 Ko
Prix
168,79 €

Suggestions personnalisées