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Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies

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Éditeur :

Springer


Collection :

Springer Theses

Paru le : 2017-06-20

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Description

This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.
Pages
79 pages
Collection
Springer Theses
Parution
2017-06-20
Marque
Springer
EAN papier
9783662546161
EAN PDF
9783662546185
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
7
Taille du fichier
3144 Ko
Prix
94,94 €
EAN EPUB
9783662546185
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
7
Taille du fichier
2263 Ko
Prix
94,94 €

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