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Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

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Éditeur :

Springer


Collection :

Current Topics in Microbiology and Immunology

Paru le : 2017-11-25

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Description


This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases.
Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.
Pages
267 pages
Collection
Current Topics in Microbiology and Immunology
Parution
2017-11-25
Marque
Springer
EAN papier
9783319689289
EAN PDF
9783319689296
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
26
Taille du fichier
1884 Ko
Prix
179,34 €
EAN EPUB
9783319689296
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
26
Taille du fichier
2120 Ko
Prix
179,34 €

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