Télécharger le livre :  Phosphoinositides and Disease

Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their...
Editeur : Springer
Parution : 2012-10-20
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
147,69

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Télécharger le livre :  Notch Regulation of the Immune System

Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident thatNotch...
Editeur : Springer
Parution : 2012-09-13
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Henipavirus

Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest human pathogens within the Paramyxoviridae family. This volume deals with the many facets of henipavirus biology, and covers our current understanding regarding the ecology, molecular...
Editeur : Springer
Parution : 2012-09-05
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Pasteurella multocida

This volume brings together contributions from experts in the field of Pasteurella research. Its covers areas such as comparative genomics, pathogenic mechanisms, bacterial proteomics, as well as a detailed description and analysis of PMT and its interaction with host...
Editeur : Springer
Parution : 2012-09-03
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
147,69

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Télécharger le livre :  Ricin and Shiga Toxins

 In May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths.  While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant...
Editeur : Springer
Parution : 2012-02-10
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Epigenetic Regulation of Lymphocyte Development

The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that...
Editeur : Springer
Parution : 2012-02-07
Collection : Current Topics in Microbiology and Immunology
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Télécharger le livre :  Mucosal Vaccines

This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal...
Editeur : Springer
Parution : 2012-01-10
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing

“The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they  act to affect gene expression and  function.  It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate...
Editeur : Springer
Parution : 2011-11-06
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Intradermal Immunization

This volume of Current Topics in Microbiology and Immunology covers diverse topics related to intradermal immunization. The  chapters highlight the effectiveness of intradermal immunization in experimental animal models or in clinical practice, all supporting the view...
Editeur : Springer
Parution : 2011-09-15
Collection : Current Topics in Microbiology and Immunology
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Télécharger le livre :  Vaccines against Allergies

We are celebrating this year the hundred years´ anniversary of allergen-specific immunotherapy. In 1911 Leonard Noon published his seminal work “Prophylactic inoculation against hay fever” describing his attempts to achieve active immunity against “grass pollen toxin”...
Editeur : Springer
Parution : 2011-08-26
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  NF-kB in Health and Disease

Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival,...
Editeur : Springer
Parution : 2011-04-26
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Cancer Immunology and Immunotherapy

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies.The present review discusses tumor-immune...
Editeur : Springer
Parution : 2011-04-11
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Negative Co-Receptors and Ligands

Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or...
Editeur : Springer
Parution : 2011-04-11
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Small-Molecule Inhibitors of Protein-Protein Interactions

In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique...
Editeur : Springer
Parution : 2011-01-18
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Phosphoinositide 3-kinase in Health and Disease

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K...
Editeur : Springer
Parution : 2010-10-17
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Phosphoinositide 3-kinase in Health and Disease

PI3K has become a very intense area of research, with over 2000 publications onPI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention withPI3K activity are high, and progress in the clinical arena is being monitored by many. However,...
Editeur : Springer
Parution : 2010-10-17
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Cell Entry by Non-Enveloped Viruses

The means by which non-enveloped viruses penetrate cellular membranes during cell entry remain poorly defined. Recent findings indicate several members of this group share a common mechanism of membrane penetration in which the virus particle undergoes programmed...
Editeur : Springer
Parution : 2010-09-30
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  The Chemokine System in Experimental and Clinical Hematology

The aim of the issue is to describe and explain the importance of the chemokine system in hematology.The chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic...
Editeur : Springer
Parution : 2010-09-30
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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Télécharger le livre :  Varicella-zoster Virus
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Télécharger le livre :  Diverse Effects of Hypoxia on Tumor Progression

Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged...
Editeur : Springer
Parution : 2010-09-28
Collection : Current Topics in Microbiology and Immunology
Format(s) : ePub
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